Vyas Ba, Vyas Rb, Joshi Sv, Santani Dd
Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Gujarat - 394 350, India.
J Young Pharm. 2011 Jan;3(1):36-40. doi: 10.4103/0975-1483.76417.
The whole-plant, Pergularia daemia (Family: Asclepediaceae), extract (50% alcohol) was investigated for its antiurolithiatic and diuretic activity. Ethylene glycol (0.75% in water) feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Alcoholic extract (400 mg/kg) of P. daemia was given orally in curative and preventive regimens over a period of 28 days. Supplementation with extract significantly (P < 0.001) lowered the urinary excretion and kidney retention levels of oxalate, calcium and phosphate. Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extract. The results were comparable with the standard drug, cystone (750 mg/kg). The reduction of stone-forming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of the extract. The extract exhibited significant diuretic activity at dose of 400 mg/kg body weight as evidenced by increased total urine volume and the urine concentration of Na(+), and K(+). These findings affirm assertions made regarding the effectiveness of the extract of this plant against urinary pathologies in the Indian folk medicine.
对萝藦科植物鲫鱼藤全草的提取物（50%乙醇提取物）进行了抗尿路结石和利尿活性研究。喂食乙二醇（0.75%溶于水）会导致高草酸尿症以及肾脏对钙和磷酸盐的排泄增加。在28天的时间里，以治疗和预防方案口服给予鲫鱼藤乙醇提取物（400毫克/千克）。提取物补充剂显著（P < 0.001）降低了草酸盐、钙和磷酸盐的尿排泄量和肾脏潴留水平。此外，提取物还显著（P < 0.001）降低了高血清尿素氮、肌酐和尿酸水平。结果与标准药物胱氨酸（750毫克/千克）相当。尿液中结石形成成分的减少及其在肾脏中潴留的减少降低了草酸钙和磷酸钙等结晶盐的溶解度积，这可能有助于提取物的抗尿路结石特性。提取物在400毫克/千克体重剂量下表现出显著的利尿活性，总尿量以及尿液中Na(+)和K(+)浓度增加证明了这一点。这些发现证实了印度民间医学中关于这种植物提取物对泌尿系统疾病有效性的说法。
