Marcellin P, Benhamou J P
Service d'Hépatologie-Gastroentérologie 2, Hôpital Beaujon, CLICHY, France.
Pathol Biol (Paris). 1995 Oct;43(8):669-73.
Infection by hepatitis C virus (HCV) generally induces an asymptomatic acute hepatitis. HCV infection becomes chronic in about 80% of cases. Chronic HCV infection is asymptomatic with persistent viremia and normal liver tests in a minority of the subjects. Chronic HCV infection is associated with chronic hepatitis with increased serum transaminases levels in the majority of the subjects. Among the patients with chronic hepatitis, the majority have minimal lesions; about 20% have a more severe disease and will develop after 5 to 20 years cirrhosis. In patients with cirrhosis, the incidence of hepatocellular carcinoma is high (around 5% per year). The factors influencing the evolution of HCV infection are not know. Alcohol is certainly an important factor. Virus related factors, such as genotype and level of replication, might also be important factors.
丙型肝炎病毒（HCV）感染通常引发无症状性急性肝炎。约80%的病例中，HCV感染会转为慢性。少数慢性HCV感染者无症状，病毒血症持续存在且肝功能检查正常。多数慢性HCV感染者会出现血清转氨酶水平升高的慢性肝炎。在慢性肝炎患者中，多数病变轻微；约20%病情较重，5至20年后会发展为肝硬化。肝硬化患者肝细胞癌的发病率很高（每年约5%）。目前尚不清楚影响HCV感染病情发展的因素。酒精肯定是一个重要因素。病毒相关因素，如基因型和复制水平，也可能是重要因素。
