Stievenart J L, Vera P, Verstichel P, Bok B, Masson M
Service de Médecine Nucléaire et Biophysique, Hôpital Beaujon, Clichy, France.
Rev Neurol (Paris). 1995 Nov;151(11):619-33.
Brain single photon emission tomography is a functional imaging modality in constant evolution. Tracers belong to 4 categories; blood pool tracers, perfusion tracers, ligands of receptors, "metabolic" tracers. Examination conditions must be accurately described since they may cause specific cerebral activation. The interpretation must be done in comparison with a morphological examination (CT or NMR). Cerebrovascular diseases, temporal lobe epilepsy and dementia were the first domains of application. Now many studies concentrate on cerebral cognitive or pharmacological activation procedure before the tracer injection to capture an aspect of the brain functioning. It is mandatory to clearly state what is expected from the examination: an answer for a given patient and a specific question or a study of an homogeneous group of patients. In order to yield relevant results, such studies must rely on a rigorous methodology.
脑单光子发射断层扫描是一种不断发展的功能成像方式。示踪剂分为4类：血池示踪剂、灌注示踪剂、受体配体、“代谢”示踪剂。必须准确描述检查条件，因为它们可能会引起特定的脑激活。解释必须与形态学检查（CT或核磁共振成像）进行对比。脑血管疾病、颞叶癫痫和痴呆是最初的应用领域。现在许多研究集中在注射示踪剂之前的脑认知或药理激活程序，以捕捉脑功能的一个方面。必须明确说明该检查期望得到什么结果：针对特定患者的特定问题给出答案，或者对一组同质患者进行研究。为了得出相关结果，此类研究必须依靠严谨的方法。
