Machlin L J, Filipski R, Nelson J, Horn L R, Brin M
J Nutr. 1977 Jul;107(7):1200-8. doi: 10.1093/jn/107.7.1200.
Rats fed a vitamin E-deficient diet containing 10% "stripped" corn oil had reduced growth rate and elevated platelet count by 12 weeks of age, and a normocytic anemia with elevated reticulocytes by 16 weeks of age. After 5 months, rats became emaciated and developed kyphoscoliosis. Some rats developed skin ulcers and tremors, and mortality was high. Neuromuscular lesions included a chronic necrotizing myopathy and localized axonal dystrophy. There was also a selective activation of lysosomes in the central nervous system microcirculation. Liver ascorbic acid of deficient rats was the same as in those receiving vitamin E. Urinary excretion of p-hydroxyphenylpyruvate after a tyrosine load was also the same in deficient and control rats. It was concluded that neither vitamin C synthesis or utilization was affected the E-deficient rats.
喂食含10%“脱除”玉米油的维生素E缺乏饮食的大鼠，到12周龄时生长速率降低，血小板计数升高，到16周龄时出现正细胞性贫血且网织红细胞升高。5个月后，大鼠消瘦并出现脊柱后凸侧弯。一些大鼠出现皮肤溃疡和震颤，死亡率很高。神经肌肉病变包括慢性坏死性肌病和局限性轴索性营养不良。中枢神经系统微循环中还存在溶酶体的选择性激活。缺乏维生素E的大鼠肝脏中的抗坏血酸与接受维生素E的大鼠相同。给予酪氨酸负荷后，缺乏维生素E的大鼠和对照大鼠对对羟基苯丙酮酸的尿排泄也相同。结论是维生素E缺乏的大鼠的维生素C合成或利用均未受到影响。
