Chow C K
J Nutr. 1975 Sep;105(9):1221-24. doi: 10.1093/jn/105.9.1221.
The effect of dietary vitamin E on activities of pyruvate kinase and lactate dehydrogenase was studied in tissues of rats. The activity of pyruvate kinase in plasma of 1-month-old male rats fed a vitamin E-deficient diet for 4 months increased 8.5-fold over that of 45 ppm vitamin E-supplemented animals. Relative to the supplemented group, the enzyme activity increased 23% (P less than 0.001) in red blood cells, was unchanged in liver and lung, and decreased 20% (P less than 0.001) in muscle of vitamin E-deficient rats. The activity of lactate dehydrogenase was not significantly altered by dietary vitamin E in all tissues measured. Similar results were obtained when 2-month-old rats were fed the respective diets for 3 months. The results suggest that vitamine E deficiency in rats may cause muscular damage and release of pyruvate kinase into blood circulation.
研究了膳食维生素E对大鼠组织中丙酮酸激酶和乳酸脱氢酶活性的影响。给1月龄雄性大鼠喂食4个月维生素E缺乏饮食后，其血浆中丙酮酸激酶的活性比补充45 ppm维生素E的动物增加了8.5倍。相对于补充组，维生素E缺乏大鼠红细胞中的酶活性增加了23%（P<0.001），肝脏和肺中的酶活性未改变，肌肉中的酶活性降低了20%（P<0.001）。在所测的所有组织中，膳食维生素E对乳酸脱氢酶的活性没有显著影响。当给2月龄大鼠喂食相应饮食3个月时，也得到了类似的结果。结果表明，大鼠维生素E缺乏可能会导致肌肉损伤以及丙酮酸激酶释放到血液循环中。
