Drago F, Ranieri E, Pastorino A, Casazza S, Crovato F, Rebora A
Department of Dermatology, University of Genoa, Italy.
Br J Dermatol. 1996 Jan;134(1):170-4.
Cutaneous lesions related to chronic active Epstein-Barr virus (EBV) infection have been rarely documented in immunocompetent patients. A 30-year-old woman, fulfilling the diagnostic criteria for the chronic fatigue syndrome, had a 10-year history of pruritic brownish macules and papules on her chest and back. Her EBV serology was abnormal; the EBV genome was present in the epidermis of lesions, in oral secretions, and in peripheral mononuclear cells (PMC). Her blood lymphocytes spontaneously outgrew in culture. Histology revealed deposits of amyloid in the papillary dermis. Treatment with acyclovir and interferon-alpha rapidly improved her condition, stopped the lymphocyte outgrowth in culture, and reduced the EBV DNA content in oral secretions and in PMC. These data support an endogenous reactivation of EBV infection and suggest a causal relationship with primary amyloidosis.
免疫功能正常的患者中，与慢性活动性EB病毒（EBV）感染相关的皮肤病变鲜有记录。一名30岁女性，符合慢性疲劳综合征的诊断标准，其胸部和背部出现瘙痒性褐色斑疹和丘疹已有10年病史。她的EBV血清学检查异常；EBV基因组存在于病变表皮、口腔分泌物及外周单核细胞（PMC）中。她的血液淋巴细胞在培养中自发生长。组织学检查显示乳头真皮中有淀粉样蛋白沉积。阿昔洛韦和α干扰素治疗迅速改善了她的病情，停止了培养中的淋巴细胞生长，并降低了口腔分泌物和PMC中的EBV DNA含量。这些数据支持EBV感染的内源性再激活，并提示其与原发性淀粉样变性存在因果关系。
