Subcellular reactions to injury. I. Ultrastructural and biochemical investigations on the hepatic cellular damage produced by haemorrhagic shock in dogs.

The ultrastructural changes produced by haemorrhagic shock in hepatocytes have been studied in dogs. The associated biochemical and biophysical system alterations allow us to propose a unitary pathogenetic mechanism of the cellular injury based on oxygen deprivation and its effect on the function and structure of the cellular compartments.