Shumiya S
Tokyo Metropolitan Institute of Gerontology, Japan.
Lab Anim Sci. 1995 Dec;45(6):671-3.
The Shumiya cataract rat (SCR) and normal control rat strains of NC1 and NC2 were established. Mean cataract appearance in adult SCR rats was 66.7%, and embryo death rate was 25%. Genetic analysis of cataract formation in the SCR was studied by breeding experiments with strains such as NC1, BUF, ACI, AD3, and normal SCR rats. No sex-based differences in cataract appearance were observed in any of the progeny. These results confirmed our hypotheses that two autosomal genes, a recessive cataract gene (ctr1), and a normal allele of a dominant cataract gene with a recessive lethal trait (Ctr2(1)) for provisional designations participated in cataract genesis in SCR (ctr1/ctr1, Ctr2(1)/Ctr2) rats. One recessive cataract gene was maintained in normal SCR, NC1 and NC2 (ctr1/ctr1, Ctr2/Ctr2) rats. The same recessive cataract gene was retained in the albumin-deficient brown hooded rat strain AD3 (ctr1/ctr1, Ctr2/Ctr2).
建立了舒米亚白内障大鼠（SCR）以及NC1和NC2正常对照大鼠品系。成年SCR大鼠的平均白内障出现率为66.7%，胚胎死亡率为25%。通过与NC1、BUF、ACI、AD3等品系以及正常SCR大鼠进行杂交实验，研究了SCR中白内障形成的遗传分析。在任何后代中均未观察到白内障出现的性别差异。这些结果证实了我们的假设，即两个常染色体基因，一个隐性白内障基因（ctr1）和一个具有隐性致死性状的显性白内障基因的正常等位基因（Ctr2(1)）（暂定名称）参与了SCR（ctr1/ctr1，Ctr2(1)/Ctr2）大鼠的白内障发生。一个隐性白内障基因在正常SCR、NC1和NC2（ctr1/ctr1，Ctr2/Ctr2）大鼠中得以保留。相同的隐性白内障基因在白蛋白缺乏的棕色帽大鼠品系AD3（ctr1/ctr1，Ctr2/Ctr2）中也被保留。
