Lindstrom F T, Ayres J W
J Pharm Sci. 1977 May;66(5):662-8. doi: 10.1002/jps.2600660514.
Numerical mathematical methods are applied to a diffusion model based on physicochemical principles to predict drug release from suspensions of drug in semisolid vehicles. The predicted mass of drug released versus time curves using this model are in agreement with some reported experimental data but differ from predictions using the classical model for semisolid suspensions. The differences are discussed in relation to the drug dissolution rate and diffusion rate in the vehicle.
数值数学方法被应用于基于物理化学原理的扩散模型，以预测药物在半固体载体中的混悬液的释放情况。使用该模型预测的药物释放质量随时间的曲线与一些报道的实验数据一致，但与半固体混悬液的经典模型预测结果不同。结合药物在载体中的溶解速率和扩散速率对这些差异进行了讨论。
