Fulminant Guillain-Barré syndrome with quadriplegia and total paresis of motor cranial nerves as a result of segmental demyelination.

Guillain-Barré syndrome (GBS) is a subacute demyelinating polyneuropathy with a monophasic course. Rarely, demyelination may be so severe as to produce electrically unexcitable nerves. We present a patient with fulminant onset of symptoms who was quadriplegic and had bilateral involvement of all motor cranial nerves. Serial EMGs indicated that segmental demyelination was responsible for these clinical findings.