Gupta V D, Ghanekar A G
J Pharm Sci. 1977 Jun;66(6):895-7. doi: 10.1002/jps.2600660649.
The quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in a liquid dosage form are described. All active and inactive ingredients (sodium benzoate and FD&C Yellow No. 5 dye) can be separated with high-pressure liquid chromatography except the two antihistamines, pheniramine maleate and pyrilamine maleate. Pheniramine maleate is determined colorimetrically, and pyrilamine maleate is determined either by difference or spectrophotometrically. The methods are simple short, accurate, and precise. The standard deviations are reported.
描述了液体制剂中磷酸可待因、愈创甘油醚、马来酸氯苯那敏、盐酸苯丙醇胺和马来酸吡拉明的定量测定方法。除两种抗组胺药马来酸氯苯那敏和马来酸吡拉明外，所有活性和非活性成分（苯甲酸钠和FD&C黄5号染料）均可通过高压液相色谱法分离。马来酸氯苯那敏采用比色法测定，马来酸吡拉明通过差值法或分光光度法测定。这些方法简单、耗时短、准确且精密。报告了标准偏差。
