Ghanekar A G, Das Gupta V
Am J Hosp Pharm. 1977 Jun;34(6):651-3.
A procedure used to assay four antihistamines--brompheniramine maleate, chlorpheniramine maleate, pheniramine maleate and pyrilamine maleate in combination--is discussed. The method requires a high-pressure liquid chromatograph and an intermediate polarity column. The method is accurate and appears to be stability-indicating. The four antihistamines can be separated and assayed accurately. There is no interference from the two commonly used decongestants, phenylephrine hydrochloride and phenylpropanolamine hydrochloride, from the expectorant potassium guaiacolsulfonate, from the preservative propyl paraben or from two other antihistamines, diphenhydramine hydrochloride and bromdiphenhydramine hydrochloride. Guaifenesin, methylparaben and sodium benzoate interfere only with pheniramine maleate. Methapyrilene hydrochloride interferes only with pyrilamine maleate.
本文讨论了一种用于联合测定四种抗组胺药——马来酸溴苯那敏、马来酸氯苯那敏、马来酸非尼拉敏和马来酸吡拉明的方法。该方法需要一台高压液相色谱仪和一根中等极性柱。该方法准确，且似乎具有稳定性指示性。这四种抗组胺药能够被准确分离和测定。常用的两种减充血剂盐酸去氧肾上腺素和盐酸苯丙醇胺、祛痰剂愈创甘油醚磺酸钾、防腐剂对羟基苯甲酸丙酯或其他两种抗组胺药盐酸苯海拉明和盐酸溴苯海拉明均无干扰。愈创甘油醚、对羟基苯甲酸甲酯和苯甲酸钠仅干扰马来酸非尼拉敏。盐酸美吡拉敏仅干扰马来酸吡拉明。
