Ghanekar A G, Das Gupta V
J Pharm Sci. 1978 Jun;67(6):873-4. doi: 10.1002/jps.2600670643.
A single method for the quantitative determinations of three active ingredients, phenylephrine hydrochloride, phenylpropanolamine hydrochloride, and brompheniramine maleate, and one inactive ingredient (sodium benzoate) in a commercial product for colds is reported. The method is based on paired ion high-pressure liquid chromatography using 1-heptanesulfonic acid as the counterion. It is accurate and precise. The relative standard deviations based on six readings are reported. This method is sensitive; less than 1 microgram of each ingredient can be assayed. The peak area of each ingredient is related to its concentration.
报道了一种用于定量测定一种感冒商业产品中三种活性成分（盐酸去氧肾上腺素、盐酸苯丙醇胺和马来酸溴苯那敏）以及一种非活性成分（苯甲酸钠）的单一方法。该方法基于使用庚烷磺酸钠作为反离子的配对离子高压液相色谱法。它准确且精密。报告了基于六次读数的相对标准偏差。该方法灵敏；每种成分的测定量可少于1微克。每种成分的峰面积与其浓度相关。
