Savill J, Haslett C
Department of Medicine, University Hospital, Nottingham, UK.
Semin Cell Biol. 1995 Dec;6(6):385-93. doi: 10.1016/s1043-4682(05)80009-1.
It has recently been recognized that extravasated granulocytes undergo apoptosis or programmed cell death. This process controls the functional longevity of these cells and is exquisitely modulated by environmental inflammatory mediators. By contrast with necrosis, an alternative fate for granulocytes in tissues, during apoptosis the granulocyte membrane remains intact and potentially injurious granule contents are retained. The intact apoptotic cell is removed by macrophages utilizing novel surface recognition mechanisms which fail to trigger a pro-inflammatory macrophage response. The balance between granulocyte apoptosis and necrosis in inflamed tissues may be an important determinant of the degree of tissue injury, and further dissection of the mechanisms of granulocyte apoptosis and removal may lead to new therapeutic strategies in inflammatory disease.
最近人们认识到，外渗的粒细胞会经历凋亡或程序性细胞死亡。这一过程控制着这些细胞的功能寿命，并受到环境炎症介质的精确调节。与坏死（粒细胞在组织中的另一种命运）相反，在凋亡过程中，粒细胞膜保持完整，潜在的有害颗粒内容物被保留。完整的凋亡细胞被巨噬细胞利用新的表面识别机制清除，这些机制不会引发促炎性巨噬细胞反应。炎症组织中粒细胞凋亡与坏死之间的平衡可能是组织损伤程度的一个重要决定因素，进一步剖析粒细胞凋亡和清除的机制可能会带来炎症性疾病的新治疗策略。
