Dagogo-Jack S
Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.
Nutrition. 1995 Sep-Oct;11(5 Suppl):643-5.
Epidermal growth factor (EGF) was first isolated from the mouse submaxillary gland, and later from human urine. The synthesis of mouse EGF is stimulated by thyroid hormone and inhibited by antithyroid therapy. EGF in turn stimulates the growth of thyroid cells. The objective of the present study was to determine whether salivary EGF levels are affected by thyroid hormone level in man. Unstimulated saliva was obtained from 13 (1 male, 12 females) untreated thyrotoxic patients (age 19-64 yr) and from 21 (2 males, 19 females) healthy controls (age 19-68 yr). After centrifugation at 1000 x g, the supernatants were assayed for human (h) EGF in a homologous radioimmunoassay. The mean +/- SEM concentration of hEGF was 0.42 +/- 0.05 nmol/L in controls compared with 0.71 +/- 0.25 nmol/L in thyrotoxic patients (p > 0.05). Thyrotoxic patients with goiter secreted significantly higher concentrations of hEGF (0.92 +/- 0.24 nmol/L) in saliva than did euthyroid controls or nongoitrous thyrotoxic patients (0.31 +/- 0.11 nmol/L, p < 0.01).
表皮生长因子（EGF）最初是从小鼠颌下腺中分离出来的，后来又从人尿中分离得到。小鼠EGF的合成受甲状腺激素刺激，而抗甲状腺治疗则会抑制其合成。反过来，EGF又会刺激甲状腺细胞的生长。本研究的目的是确定人类唾液中EGF水平是否受甲状腺激素水平的影响。从未经治疗的13名（1名男性，12名女性）甲状腺毒症患者（年龄19 - 64岁）和21名（2名男性，19名女性）健康对照者（年龄19 - 68岁）中获取非刺激性唾液。在1000×g离心后，用同源放射免疫分析法检测上清液中的人（h）EGF。对照组中hEGF的平均±标准误浓度为0.42±0.05 nmol/L，而甲状腺毒症患者为0.71±0.25 nmol/L（p>0.05）。患有甲状腺肿的甲状腺毒症患者唾液中hEGF的分泌浓度（0.92±0.24 nmol/L）明显高于甲状腺功能正常的对照者或无甲状腺肿的甲状腺毒症患者（0.31±0.11 nmol/L，p<0.01）。
