Ohmura E, Emoto N, Tsushima T, Watanabe S, Takeuchi T, Kawamura M, Shigemoto M, Shizume K
Department of Medicine, Institute of Clinical Endocrinology and Institute of Gastroenterology, Tokyo.
Hepatogastroenterology. 1987 Aug;34(4):160-3.
EGF is reported to have a potent protective effect on peptic ulcer formation in rats. In this study, we measured the IR-hEGF concentrations in the saliva of normal human subjects and patients with peptic ulcer disease or non-peptic ulcer gastroduodenal disease. In normal subjects, the level of salivary IR-hEGF was highest in the early morning, and the values in individuals on different days showed small variations. There were no sex differences or age-related changes in the salivary IR-hEGF levels. The concentrations of the peptide were lower in patients in the active (0.96 +/- 26 ng/ml, mean +/- SE, n = 4) and healing stages (1.06 +/- 0.24 ng/ml, n = 8) of peptic ulcer disease as compared with those in normal subjects (3.19 +/- 0.46 ng/ml, n = 47). No significant differences in salivary IR-hEGF levels were observed between normal subjects and patients in the scaring stage of peptic ulcer disease (2.40 +/- 0.42 ng/ml, n = 21), or those with gastric cancer (2.44 +/- 0.27 ng/ml, n = 21) and atrophic or superficial gastritis (2.31 +/- 0.34 ng/ml, n = 28). Although the pathophysiological significance of these lower salivary IR-hEGF levels in patients with peptic ulcer disease is unclear, it is possible that the low level of hEGF in saliva may decrease the resistance of the mucosa to physicochemical stress, and thus participate in the development of the diseases.
据报道，表皮生长因子（EGF）对大鼠消化性溃疡的形成具有强大的保护作用。在本研究中，我们测定了正常人类受试者以及患有消化性溃疡疾病或非消化性溃疡胃十二指肠疾病患者唾液中免疫反应性人表皮生长因子（IR-hEGF）的浓度。在正常受试者中，唾液IR-hEGF水平在清晨最高，且不同日期个体的值变化较小。唾液IR-hEGF水平不存在性别差异或与年龄相关的变化。与正常受试者（3.19±0.46 ng/ml，n = 47）相比，消化性溃疡疾病活动期（0.96±26 ng/ml，平均值±标准误，n = 4）和愈合期（1.06±0.24 ng/ml，n = 8）患者的该肽浓度较低。在消化性溃疡疾病瘢痕期患者（2.40±0.42 ng/ml，n = 21）、胃癌患者（2.44±0.27 ng/ml，n = 21）以及萎缩性或浅表性胃炎患者（2.31±0.34 ng/ml，n = 28）与正常受试者之间，未观察到唾液IR-hEGF水平有显著差异。尽管消化性溃疡疾病患者唾液中这些较低的IR-hEGF水平的病理生理意义尚不清楚，但唾液中hEGF水平较低可能会降低黏膜对物理化学应激的抵抗力，从而参与疾病的发展。
