Miner L L, Marley R J
Molecular Neurobiology Branch, NIDA/ARC, Baltimore, MD 21224, USA.
Psychopharmacology (Berl). 1995 Dec;122(3):209-14. doi: 10.1007/BF02246541.
To elucidate genes associated with cocaine's locomotor stimulant effects, we used recombinant inbred-quantitative trait loci (RI-QTL) analyses to identify chromosomal loci associated with locomotor activity before (baseline) and after cocaine treatment. RI-QTL analyses seek to identify associations between a quantitative measure of a phenotype and one or more previously mapped marker loci across a panel of RI strains. In the present study, 11 BXD RI strains were used to identify several putative QTLs for each phenotype. Both baseline locomotor activity and cocaine's locomotor stimulant effects are polygenic, with both unique and overlapping genetic influences. The largest associations for baseline activity were observed on chromosomes 5 and 9 and the largest associations for cocaine's psychomotor stimulant effects on chromosomes 3 and 17.
为了阐明与可卡因运动刺激效应相关的基因，我们使用重组近交系-数量性状基因座（RI-QTL）分析来识别可卡因处理前后（基线）与运动活性相关的染色体基因座。RI-QTL分析旨在识别一组RI品系中表型的定量测量值与一个或多个先前定位的标记基因座之间的关联。在本研究中，使用11个BXD RI品系来识别每种表型的几个假定QTL。基线运动活性和可卡因的运动刺激效应均为多基因性，具有独特和重叠的遗传影响。在5号和9号染色体上观察到与基线活性的最大关联，在3号和17号染色体上观察到与可卡因精神运动刺激效应的最大关联。
