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帕金森病中的自主神经功能障碍。

Autonomic disorders in Parkinson's disease.

作者信息

Martignoni E, Pacchetti C, Godi L, Micieli G, Nappi G

机构信息

Department of Neurology, Parkinson's Disease Centre, IRCCS-C.Mondino, University of Pavia, Italy.

出版信息

J Neural Transm Suppl. 1995;45:11-9.

PMID:8748604
Abstract

Patients with idiopathic Parkinson's disease (IPD) often show signs and symptoms of autonomic involvement, related to the disease itself or to its progression. The more frequently disturbances reported are connected with loss of extrapyramidal motor control, i.e. dysphagia, gastric emptying and the most common constipation. They concern about 73% of the patients. A high frequency of urinary symptoms, ranging from 37% to 71%, is also reported in IPD, in particular detrusor hyperreflexia causing urgency, frequency of micturing or urgency incontinence. Another autonomic groups of symptoms are related to the failure of cardiopressor adaptability which involve 15% of the subjects and are more typical of late onset cases or forms bordering with the Multiple System Atrophy, finally resulting in orthostatic hypotension (OH).

摘要

特发性帕金森病(IPD)患者常表现出自主神经受累的体征和症状,这与疾病本身或其进展有关。报告中较常见的功能障碍与锥体外系运动控制丧失有关,即吞咽困难、胃排空和最常见的便秘。这些症状在约73%的患者中出现。IPD患者中还报告了较高频率的泌尿系统症状,发生率在37%至71%之间,特别是逼尿肌反射亢进导致尿急、尿频或急迫性尿失禁。另一组自主神经症状与心脏升压适应性衰竭有关,涉及15%的患者,在晚发型病例或与多系统萎缩交界的类型中更为典型,最终导致体位性低血压(OH)。

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