Bonnet A M, Pichon J, Vidailhet M, Gouider-Khouja N, Robain G, Perrigot M, Agid Y
INSERM U 289, Hôpital de la Salpêtrière, Paris, France.
Mov Disord. 1997 Jul;12(4):509-13. doi: 10.1002/mds.870120406.
Although urinary disturbances are more frequent in multiple system atrophy (MSA) than in Parkinson's disease (PD), the striatonigral degeneration (SND) type of MSA is difficult to distinguish from PD, especially when the latter is associated with orthostatic hypotension or urinary symptoms. The pattern of urinary symptoms and urodynamic dysfunction was analyzed in 15 SND and 35 PD patients with urinary complaints. In SND, dysuria with or without chronic retention, frequently associated with a hypoactive detrusor and low urethral pressure, permitted early and reliable diagnosis. In PD, urgency to void, with or without difficulty voiding, but without chronic retention, associated with detrusor hyperreflexia and normal urethral sphincter function, predominated. In clinical practice, the study of urinary symptoms and bladder function may help to distinguish SND from PD in patients with urinary disturbances.
尽管多系统萎缩（MSA）中泌尿功能障碍比帕金森病（PD）更常见，但MSA的纹状体黑质变性（SND）类型很难与PD区分开来，尤其是当后者伴有体位性低血压或泌尿症状时。对15例有泌尿主诉的SND患者和35例PD患者的泌尿症状和尿动力学功能障碍模式进行了分析。在SND中，伴或不伴慢性尿潴留的排尿困难，常与逼尿肌活动减退和尿道压力低相关，有助于早期可靠诊断。在PD中，以排尿急迫感伴或不伴排尿困难但无慢性尿潴留为主，与逼尿肌反射亢进和尿道括约肌功能正常相关。在临床实践中，对泌尿症状和膀胱功能的研究可能有助于在有泌尿功能障碍的患者中将SND与PD区分开来。
