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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Blair-West J R, Brook A H, Simpson P A

J Physiol. 1977 May;267(2):321-38. doi: 10.1113/jphysiol.1977.sp011815.

The extent to which renin release is affected by simultaneous changes in body Na and body fluid volume was studied in six sheep. 2. The animals' water intake was restricted for 10-17 days after which they were offered solutions containing varying amounts of NaCl. 3. Plasma renin concentration (PRC) of water restricted sheep was 2-3 times normal. 4. The changes in PRC following drinking were inversely related to the amount of sodium consumed, Na excretion and plasma Na concentration. There was no correlation between the changes of PRC and of plasma volume in so far as the latter is reflected by alterations in plasma protein concentration. 5. We conclude that changes in renin release were related to the animals' handling of NA, and not to alterations in body fluid volume. 6. These findings are compatible with the proposition that renin release was mediated by a macula densa mechanism.

在六只绵羊身上研究了肾素释放受机体钠和体液量同时变化影响的程度。2. 动物的水摄入量被限制10 - 17天，之后给它们提供含有不同量氯化钠的溶液。3. 限水绵羊的血浆肾素浓度（PRC）是正常水平的2 - 3倍。4. 饮水后PRC的变化与钠摄入量、钠排泄量和血浆钠浓度呈负相关。就血浆蛋白浓度变化所反映的血浆量变化而言，PRC的变化与之无相关性。5. 我们得出结论，肾素释放的变化与动物对钠的处理有关，而与体液量的改变无关。6. 这些发现与肾素释放由致密斑机制介导的观点相符。

Blair-West J R, Brook A H, Simpson P A

J Physiol. 1977 May;267(2):321-38. doi: 10.1113/jphysiol.1977.sp011815.

The extent to which renin release is affected by simultaneous changes in body Na and body fluid volume was studied in six sheep. 2. The animals' water intake was restricted for 10-17 days after which they were offered solutions containing varying amounts of NaCl. 3. Plasma renin concentration (PRC) of water restricted sheep was 2-3 times normal. 4. The changes in PRC following drinking were inversely related to the amount of sodium consumed, Na excretion and plasma Na concentration. There was no correlation between the changes of PRC and of plasma volume in so far as the latter is reflected by alterations in plasma protein concentration. 5. We conclude that changes in renin release were related to the animals' handling of NA, and not to alterations in body fluid volume. 6. These findings are compatible with the proposition that renin release was mediated by a macula densa mechanism.

在六只绵羊身上研究了肾素释放受机体钠和体液量同时变化影响的程度。2. 动物的水摄入量被限制10 - 17天，之后给它们提供含有不同量氯化钠的溶液。3. 限水绵羊的血浆肾素浓度（PRC）是正常水平的2 - 3倍。4. 饮水后PRC的变化与钠摄入量、钠排泄量和血浆钠浓度呈负相关。就血浆蛋白浓度变化所反映的血浆量变化而言，PRC的变化与之无相关性。5. 我们得出结论，肾素释放的变化与动物对钠的处理有关，而与体液量的改变无关。6. 这些发现与肾素释放由致密斑机制介导的观点相符。