Wittenberg C, Choshniak I, Shkolnik A, Thurau K, Rosenfeld J
Pflugers Arch. 1986 Apr;406(4):405-8. doi: 10.1007/BF00590944.
Bedouin goats in the extreme deserts of the Middle East are regularly subjected to severe dehydration and possess a capacity to rapidly rehydrate by drinking large volumes of water. Urine flow, glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) in the fully hydrated animals amounted to 0.74 +/- 0.4 ml X min-1, 76 +/- 29 ml X min-1 and 344 +/- 146 ml X min-1 respectively. In goats that were dehydrated to a loss of about 30% of their initial body weight, urine flow dropped to 24% of the value recorded in the hydrated animals and GFR and ERPF dropped to half their level recorded in the hydrated phase. Na and K+ excretion decreased in the water depleted goats and further decrease was recorded following drinking. Following drinking the urine flow, GFR and ERPF of the recently rehydrated goats dropped to below the rates recorded in the dehydrated animals. During the 3 h of the continuous recording that followed the drinking, all three rates did not exceed the predrinking level. Plasma renin activity amounted to 0.37 +/- 0.32 ng AI X ml-1 X h-1 in the hydrated animals. In dehydrated ones it amounted to 4.8 +/- 2.8 ng AI X ml-1 X h-1 and a further increase was recorded following drinking. Aldosterone in the hydrated goats was 5.5 +/- 4.3 ng% and increased to 13.9 +/- 2.3 ng% in the dehydrated animal and amounted to 20.1 +/- 5.5 ng% 2 h following drinking.(ABSTRACT TRUNCATED AT 250 WORDS)
中东极端沙漠地区的贝都因山羊经常面临严重脱水，但它们具备通过大量饮水迅速补充水分的能力。完全补水的山羊的尿流量、肾小球滤过率（GFR）和有效肾血浆流量（ERPF）分别为0.74±0.4毫升×分钟⁻¹、76±29毫升×分钟⁻¹和344±146毫升×分钟⁻¹。在脱水至初始体重约减轻30%的山羊中，尿流量降至补水山羊记录值的24%，GFR和ERPF降至补水阶段记录水平的一半。缺水山羊的钠和钾排泄减少，饮水后进一步减少。饮水后，近期补水山羊的尿流量、GFR和ERPF降至脱水动物记录的速率以下。在饮水后的连续3小时记录中，所有这三个速率均未超过饮水前水平。补水山羊的血浆肾素活性为0.37±0.32纳克AI×毫升⁻¹×小时⁻¹。脱水山羊的血浆肾素活性为4.8±2.8纳克AI×毫升⁻¹×小时⁻¹，饮水后进一步升高。补水山羊的醛固酮为5.5±4.3纳克%，脱水动物中升至13.9±2.3纳克%，饮水后2小时为20.1±5.5纳克%。（摘要截断于250字）
