Kubes P
Department of Physiology, University of Calgary Medical Center, Alberta, Canada.
Microcirculation. 1995 Sep;2(3):235-44. doi: 10.3109/10739689509146769.
There is a growing body of evidence that nitric oxide modulates the movement of fluid and protein out of the vasculature. However, the results obtained from whole organ, single vessel, and endothelial monolayer studies are often not consistent. In fact, there is much evidence that endogenous nitric oxide increases microvascular permeability and equally compelling evidence to suggest that endogenous nitric oxide decreases microvascular permeability. In this review we summarize and critically evaluate the data published to date regarding the role of nitric oxide as a modulator of microvascular permeability under both normal conditions and following exposure to various stimuli. The last section of the chapter discusses the importance of nitric oxide as a modulator of microvascular permeability in inflammatory conditions. Particular emphasis is placed on the stimuli used, the organ systems studied, and the measurements performed to investigate the effects of nitric oxide on microvascular permeability alterations.
越来越多的证据表明，一氧化氮可调节液体和蛋白质从脉管系统中流出。然而，从全器官、单血管和内皮单层研究中获得的结果往往不一致。事实上，有许多证据表明内源性一氧化氮会增加微血管通透性，同时也有同样有说服力的证据表明内源性一氧化氮会降低微血管通透性。在这篇综述中，我们总结并批判性地评估了迄今为止发表的关于一氧化氮在正常条件下以及暴露于各种刺激后作为微血管通透性调节剂的作用的数据。本章的最后一部分讨论了一氧化氮作为微血管通透性调节剂在炎症条件下的重要性。特别强调了所使用的刺激、所研究的器官系统以及为研究一氧化氮对微血管通透性改变的影响而进行的测量。
