Nagele A
Strahlenbiologisches Institut, Ludwig-Maximilians-Universitaet Muenchen, Schillerstrasse 42, Muenchen, Germany.
Radiat Environ Biophys. 1995 Nov;34(4):251-4. doi: 10.1007/BF01209751.
Poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30) is an abundant nuclear protein that is highly conserved and constitutively expressed in all higher eukaryotic cells investigated. Today, after about two decades of intensive research, we have a fairly comprehensive picture of its remarkable enzymatic functions and of its molecular structure. Its physiological role, however, remains controversial. The present hypothesis attempts to reconcile the different findings. By extending an earlier hypothesis, it is proposed that poly(ADP-ribosyl)ation is primarily a mechanism to prevent survival of mutated, possibly apoptosis-incompetent, cells after acute DNA-damage. Recent reviews on PARP may be found in [1-4].
聚（ADP-核糖）聚合酶（PARP，EC 2.4.2.30）是一种丰富的核蛋白，在所有被研究的高等真核细胞中高度保守且组成性表达。如今，经过大约二十年的深入研究，我们对其卓越的酶促功能和分子结构有了相当全面的了解。然而，其生理作用仍存在争议。本假说试图调和不同的研究结果。通过扩展早期的假说，有人提出聚（ADP-核糖基）化主要是一种在急性DNA损伤后防止突变的、可能无凋亡能力的细胞存活的机制。关于PARP的近期综述可见于[1 - 4]。
