单侧椎动脉闭塞对大鼠双侧内耳血流的影响。

The influence of unilateral vertebral artery occlusion on bilateral inner ear blood flow in rats.

作者信息

Ueda T, Inui H, Fujita N, Matsunaga T

机构信息

Department of Otorhinolaryngology, Nara Medical University, Japan.

出版信息

Acta Otolaryngol Suppl. 1995;520 Pt 2:384-6. doi: 10.3109/00016489509125277.

DOI:10.3109/00016489509125277

PMID:8749168

Abstract

We investigated the influence of unilateral vertebral artery (VA) occlusion on bilateral inner ear blood flow in rats using laser Doppler flowmetry for the measurement of bilateral cochlear blood flow (CBF) and photochemically initiated thrombosis for VA occlusion. BP and CBF showed little change by unilateral VA occlusion alone. However, subsequent hypotension induced by venesection not only reduced CBF but also caused imbalance between bilateral CBF reduction rates. CBF changed independently of BP, indicating the existence of a local CBF regulatory system.

摘要

我们使用激光多普勒血流仪测量双侧耳蜗血流（CBF），并通过光化学诱导血栓形成来阻断椎动脉（VA），研究了单侧椎动脉阻断对大鼠双侧内耳血流的影响。单纯单侧椎动脉阻断时，血压和CBF变化很小。然而，随后静脉切开引起的低血压不仅降低了CBF，还导致双侧CBF降低率失衡。CBF的变化独立于血压，表明存在局部CBF调节系统。