Ueda T, Murai T, Nario K, Fujita N, Miyahara H, Matsunaga T
Department of Otorhinolaryngology, Nara Medical University, Kashihara-city, Japan.
Acta Otolaryngol Suppl. 1998;533:36-9.
It is generally accepted that certain kinds of vertigo and hearing disturbances are caused by blood flow insufficiency in the vertebrobasilar arterial system. Using the microsphere method we investigated whether unilateral vertebral artery or unilateral posterior inferior cerebellar artery occlusion could cause an imbalance between right and left inner ear blood flow in rats. We also studied the differential vulnerability between blood flow in the cochlea and in the ampullae of the three semicircular canals. We counted the numbers of microspheres distributed to the cochlea (CO) and microspheres distributed to three ampullae of semicircular canals (SC) under a microscope with the surface preparation method. The results were as follows: i) no imbalances were observed between bilateral CO or SC even in animals with arterial occlusion, and ii) the CO/SCs of animals with arterial occlusion were not significantly different from that of the control animals. These findings suggest that total inner ear blood flow over a certain period of time was even between the ears bilaterally even in animals with arterial occlusion. The blood flow in the ampullae of the three semicircular canals was not more or less affected by arterial occlusion than the blood flow in the cochlea.
一般认为，某些类型的眩晕和听力障碍是由椎基底动脉系统的血流不足引起的。我们使用微球法研究了单侧椎动脉闭塞或单侧小脑后下动脉闭塞是否会导致大鼠左右内耳血流失衡。我们还研究了耳蜗和三个半规管壶腹血流的不同易损性。我们采用表面制备法，在显微镜下计数分布到耳蜗（CO）的微球数量和分布到三个半规管壶腹（SC）的微球数量。结果如下：i）即使在动脉闭塞的动物中，双侧CO或SC之间也未观察到失衡，ii）动脉闭塞动物的CO/SC与对照动物无显著差异。这些发现表明，即使在动脉闭塞的动物中，某一时间段内双侧内耳的总血流量在双耳之间也是均匀的。动脉闭塞对半规管壶腹血流的影响并不比耳蜗血流的影响更大或更小。
