Kitahara T, Saika T, Takeda N, Kiyama H, Kubo T
Department of Neuroanatomy, Osaka University Medical School, Japan.
Acta Otolaryngol Suppl. 1995;520 Pt 2:401-4. doi: 10.3109/00016489509125282.
By means of immunohistochemical technique, we examined the changes in Fos and Jun expression after unilateral labyrinthectomy (UL) in the rat brainstem. We observed Fos-like immunoreactivity (-LIR) in the ipsilateral medial vestibular nucleus (ipsi-MVe), the contralateral prepositus hypoglossal nucleus (contra-PrH) and the contralateral inferior olive beta subnucleus (contra-IOb) 1 h after UL. Then, Fos expression in the contra-PrH and the contra-IOb disappeared 3 days after surgery. However, we still found the residual expression in the ipsi-MVe, which disappeared within 7 days. On the other hand, no Jun-LIR was detected in the vestibular or vestibular-related nuclei before or after the operation. Fos expression in the MVe, PrH and IOb was induced immediately after UL. Then, the Fos expression disappeared in accordance with the development of the vestibular compensation. These findings suggest that the transient Fos expression in the vestibular and vestibular related nuclei is a trigger of vestibular compensation.
通过免疫组织化学技术，我们检测了大鼠脑干单侧迷路切除术（UL）后Fos和Jun表达的变化。我们观察到，UL后1小时，在同侧内侧前庭核（ipsi-MVe）、对侧舌下前置核（contra-PrH）和对侧下橄榄核β亚核（contra-IOb）中有Fos样免疫反应性（-LIR）。然后，术后3天，contra-PrH和contra-IOb中的Fos表达消失。然而，我们仍在ipsi-MVe中发现残留表达，其在7天内消失。另一方面，术前和术后在前庭或前庭相关核中均未检测到Jun-LIR。UL后，MVe、PrH和IOb中立即诱导出Fos表达。然后，Fos表达随着前庭代偿的发展而消失。这些发现表明，前庭和前庭相关核中短暂的Fos表达是前庭代偿的触发因素。
