Zaleski M B, Thacore H R, Zhou P, Dubiski S, Nakeeb S, Cunningham R K
Department of Microbiology, Toronto, Ontario, Canada.
Immunobiology. 1995 Nov;194(4-5):390-402. doi: 10.1016/S0171-2985(11)80106-3.
The mice born to female mice infected with LP-BM5 MuLV, the etiologic agent for lymphoproliferative disease and nursed for 4-6 weeks by them were less susceptible upon reinfection by i.v. transfusion of blood or plasma from infected donors with fully developed disease. Sera of 7 week or older perinatally exposed mice were capable of a complete in vitro neutralization of virus in plasma or blood from mice with fully developed disease. In contrast, sera from 3-week old perinatally exposed mice were ineffective. The neutralizing ability of the sera was drastically reduced or abrogated after their absorption with anti-mouse IgM. These observations are consistent with the notion that perinatally exposure results ina moderate form of the disease of the offspring. This perinatal infection is followed by a production of neutralizing antibodies of predominantly the IgM class that significantly alters the course of the lymphoproliferative disease and, in some instances, even prevents its development.
感染了淋巴细胞增生性疾病的病原体LP - BM5 MuLV的雌性小鼠所生的小鼠，由它们哺育4至6周，经静脉输注来自患有完全发展疾病的感染供体的血液或血浆再次感染时，易感性较低。出生时暴露的7周龄或更大龄小鼠的血清能够在体外完全中和患有完全发展疾病的小鼠血浆或血液中的病毒。相比之下，出生时暴露的3周龄小鼠的血清则无效。这些血清在被抗小鼠IgM吸收后，其中和能力急剧降低或丧失。这些观察结果与以下观点一致，即出生时暴露会导致后代出现中度形式的疾病。这种围产期感染之后会产生主要为IgM类的中和抗体，这些抗体显著改变淋巴细胞增生性疾病的进程，在某些情况下甚至可阻止其发展。
