Cunningham R K, Thacore H R, Zhou P, Nakeeb S, Zaleski M B
Ernest Witebsky Center for Immunology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo 14214-3078, USA.
Immunol Invest. 1995 Nov;24(6):881-90. doi: 10.3109/08820139509060714.
The effect of graft-versus-host reaction on the course of concommitant retrovirus-induced lymphoproliferative disease was investigated. The graft-versus-host reaction was elicited by a single i.v. injection of 1.2 x 10(8) parental spleen cells into adult F1 mice. Lymphoproliferative disease was induced by a single transfusion of 0.2 ml of whole blood from donors with fully developed disease, induced by infection with retrovirus LP-BM5 MuLV. Graft-versus-host reaction and the lymphoproliferative disease each separately produced similar syndrome consisting of splenomegaly, lymphadenopathy, leukopenia, neutrophilia, reduced in vitro proliferation of spleen cells and suppression of in vivo immune responsiveness. The above symptoms were usually less pronounced during graft-versus-host reaction. Ongoing graft-versus-host reaction neither aggravated nor accelerated the course of the virus-induced lymphoproliferative disease in genetically susceptible F1 hybrids. Likewise, an ongoing graft-versus-host reaction in genetically resistant F1 hybrids did not alter their susceptibility to the retrovirus infection. The apparent lack of the effect of graft-versus-host reaction -dependent immunosuppression on the severity and the course of the concommitant retrovirus-induced lymphoproliferative disease suggests pathogenic differences between the murine syndrome and human AIDS for which the murine disease is considered by some to be an animal model.
研究了移植物抗宿主反应对伴发的逆转录病毒诱导的淋巴细胞增生性疾病病程的影响。通过向成年F1小鼠静脉内单次注射1.2×10⁸个亲代脾细胞引发移植物抗宿主反应。通过单次输注0.2 ml来自感染逆转录病毒LP - BM5 MuLV而患有完全发展疾病的供体的全血来诱导淋巴细胞增生性疾病。移植物抗宿主反应和淋巴细胞增生性疾病各自分别产生类似的综合征，包括脾肿大、淋巴结病、白细胞减少、嗜中性粒细胞增多、脾细胞体外增殖减少以及体内免疫反应性抑制。上述症状在移植物抗宿主反应期间通常不太明显。持续的移植物抗宿主反应既不加重也不加速基因易感的F1杂种中病毒诱导的淋巴细胞增生性疾病的病程。同样，基因抗性的F1杂种中持续的移植物抗宿主反应也不会改变它们对逆转录病毒感染的易感性。移植物抗宿主反应依赖性免疫抑制对伴发的逆转录病毒诱导的淋巴细胞增生性疾病的严重程度和病程明显缺乏影响，这表明小鼠综合征与人类艾滋病之间存在致病性差异，有人认为小鼠疾病是人类艾滋病的动物模型。
