Hilgenfeld R
Institute of Molecular Biotechnology, Jena, Germany.
Curr Opin Struct Biol. 1995 Dec;5(6):810-7. doi: 10.1016/0959-440x(95)80015-8.
The past year has witnessed a tremendous increase in our understanding of the structures and interactions of the GTPases. The highlights include crystal structures of G alpha subunits, as well as the first complex between a GTPase (Rap1A) and an effector molecule (c-Raf1 Ras-binding domain). In the field of elongation factors (EFs), three very important structures have been determined: EF-G, the ternary complex of EF-Tu.GTP with aminoacyl-tRNA, and the EF-Tu.EF-Ts complex.
过去一年里，我们对GTP酶的结构和相互作用的理解有了极大的提升。其中的亮点包括Gα亚基的晶体结构，以及首个GTP酶（Rap1A）与效应分子（c-Raf1 Ras结合结构域）之间的复合物。在延伸因子（EF）领域，已经确定了三个非常重要的结构：EF-G、EF-Tu·GTP与氨酰tRNA的三元复合物，以及EF-Tu·EF-Ts复合物。
