Choi H K, Seong D H, Rha K H
Severance Institute of Andrology Research, Yonsei University, College of Medicine, Seoul, Korea.
Int J Impot Res. 1995 Sep;7(3):181-6.
To investigate the efficacy in treating erectile dysfunction and to develop a natural drug without complications, the results of ginseng treatments are compared to placebo and other drug. A total of 90 patients with 30 patients in each group were closely followed. Changes in symptoms such as frequency of intercourse, premature ejaculation, and morning erections after treatment were not changed in all three groups (p > 0.05). However in the group receiving ginseng, changes in early detumescence and erectile parameters such as penile rigidity and girth, libido and patient satisfactions were significantly higher than that of other groups (p < 0.05). The overall therapeutic efficacies on erectile dysfunction were 60% for ginseng group and 30% for placebo and trazodone treated groups, statistically confirming the effect of ginseng (p < 0.05). No complete remission of erectile dysfunction was noted, but partial responses were reported. No cases of aggravation of symptoms were reported. AVS-penogram, which is a recording of penile hemodynamic changes during the natural erection after audiovisual erotic stimulation, is not changed after administration of ginseng. However if administered for a prolonged period of time, the cummulative effect on vascular flow might be seen. The administration of Korean red ginseng has shown to have superior effects compared to the placebo or trazodone. Definitely more researches are required to elucidate the mechanism of ginseng. The effects of saponin, extracted from ginseng, on smooth muscle of erectile tissues, can be evaluated using organ chamber or nitric oxide titration, thereby pinpointing the exact action mechanism of saponin. As more informations are available, possible breakthrough in treatment of erectile dysfunction could be arisen from active saponin extracted from red ginseng, bringing hopes to many sufferers of erectile dysfunction.
为了研究治疗勃起功能障碍的疗效并开发一种无并发症的天然药物，将人参治疗的结果与安慰剂和其他药物进行了比较。总共90名患者，每组30名，进行了密切随访。治疗后三组在性交频率、早泄和晨勃等症状方面均无变化（p>0.05）。然而，在接受人参治疗的组中，早期消肿以及勃起参数如阴茎硬度和周长、性欲和患者满意度的变化显著高于其他组（p<0.05）。人参组对勃起功能障碍的总体治疗有效率为60%，安慰剂组和曲唑酮治疗组为30%，统计学上证实了人参的效果（p<0.05）。未观察到勃起功能障碍完全缓解的情况，但有部分反应的报告。未报告症状加重的病例。视听性刺激后自然勃起过程中阴茎血流动力学变化的记录——AVS阴茎造影，在服用人参后没有改变。然而，如果长期给药，可能会看到对血管血流的累积效应。与安慰剂或曲唑酮相比，韩国红参的给药已显示出更好的效果。显然需要更多的研究来阐明人参的作用机制。从人参中提取的皂苷对勃起组织平滑肌的作用，可以使用器官腔或一氧化氮滴定法进行评估，从而确定皂苷的确切作用机制。随着更多信息的获得，从红参中提取的活性皂苷可能会在勃起功能障碍的治疗上取得突破，给许多勃起功能障碍患者带来希望。
