Haeusler M C, Hoellwarth M E, Holzer P
Department of Obstetrics and Gynaecology, University of Graz, Austria.
Prenat Diagn. 1995 Dec;15(12):1165-7. doi: 10.1002/pd.1970151214.
Paralytic ileus of the small bowel was diagnosed in a fetus at 32 weeks' gestation after referral because of polyhydramnios. The mother had taken clonazepam, a benzodiazepine, and carbamazepine during the entire pregnancy for epilepsy. All known causes for the ileus were ruled out and at 20 months the boy has developed normally. We conclude that maternal anticonvulsant drug intake was very likely the cause of the paralytic ileus. This side-effect is known in experimental and clinical pharmacology but has not yet been described in human fetuses.
一名妊娠32周的胎儿因羊水过多转诊后被诊断为小肠麻痹性肠梗阻。母亲在整个孕期因癫痫服用了氯硝西泮（一种苯二氮䓬类药物）和卡马西平。所有已知的肠梗阻病因均被排除，该男孩在20个月时发育正常。我们得出结论，母亲服用抗惊厥药物很可能是麻痹性肠梗阻的病因。这种副作用在实验和临床药理学中是已知的，但尚未在人类胎儿中描述过。
