一名接受卡马西平治疗的癫痫孕妇的胎儿畸形

Fetal malformations in an epileptic pregnant woman treated with carbamazepine.

作者信息

Ceci O, Loizzi P, Caruso G, Caradonna F, Clemente R, Ferreri R

机构信息

Second Department of Obstetrics and Gynaecology, University of Bari, Italy.

出版信息

Zentralbl Gynakol. 1996;118(3):169-71.

PMID:8900607

Abstract

We report a case of an epileptic pregnant woman at 20 weeks of gestation treated with carbamazepine, whose fetus was affected by major malformations probably due to the drug teratogenicity. After a therapeutic abortion minor malformations were also found. After seven months the patient was pregnant again, at 14 weeks of gestation she aborted spontaneously a fetus with no malformations. During this pregnancy the patient took a reduced dosage of carbamazepine.

摘要

我们报告一例妊娠20周的癫痫孕妇，其接受卡马西平治疗，其胎儿可能因药物致畸作用而受到严重畸形影响。治疗性流产后也发现了轻微畸形。七个月后患者再次怀孕，妊娠14周时自然流产了一个无畸形的胎儿。此次妊娠期间患者服用了减量的卡马西平。