Bradlyn A S, Pollock B H
Department of Behavioral Medicine and Psychiatry, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown 26505, USA.
J Natl Cancer Inst Monogr. 1996(20):49-53.
Quality-of-life end points for cancer clinical trials have received much attention in the adult literature. However, within pediatric cancer clinical trials, the inclusion of these alternate end points has only recently been considered. We review the Pediatric Oncology Group's approach to research in this area and describe our guidelines and protocols that incorporate quality-of-life end points and several of the methodologic barriers that must be addressed.
癌症临床试验中的生活质量终点在成人文献中受到了广泛关注。然而，在儿科癌症临床试验中，纳入这些替代终点只是最近才被考虑。我们回顾了儿科肿瘤学组在该领域的研究方法，并描述了我们纳入生活质量终点的指南和方案，以及一些必须解决的方法学障碍。
