Department of Health Disparities Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77230-1439, USA.
Psychooncology. 2010 Sep;19(9):997-1003. doi: 10.1002/pon.1654.
Survivors of childhood cancer are at an increased risk for reduced quality of life (QOL), yet few studies have explored factors associated with improving health-related QOL (HRQOL) in this population. We thus explored the relationship between physical activity (PA) and HRQOL among survivors of childhood cancer.
A total of 215 survivors of childhood lymphoma, leukemia, and central nervous system cancers completed mailed surveys that elicited information regarding leisure-time PA (LTPA) measured in metabolic equivalents, HRQOL, and diagnostic and demographic factors. Correlations and adjusted regression models were used to explore the relationship between LTPA and HRQOL.
In the total sample, modest, yet significant linear associations were observed between LTPA and overall HRQOL (beta=0.17, p<0.01), as well as each of the respective subscales (beta=0.11-0.23 and p's<0.05 to <0.001). Among adolescent survivors of childhood cancer, LTPA was significantly associated with overall HRQOL (beta=0.27), cancer worry (beta=0.36), cognitive function (beta=0.32), body appearance (beta=0.29), and social function (beta=0.27) (all p's<0.05). Among adult survivors of childhood cancer, LTPA was only significantly associated with physical function (beta=0.28, p<0.001).
Significant associations exist between LTPA and HRQOL; however, the association was stronger and observed in more domains for adolescent survivors of childhood cancer. More research is needed to determine the antecedents and consequences of PA in this population.
儿童癌症幸存者的生活质量（QOL）降低的风险增加，但很少有研究探讨与改善这一人群健康相关的 QOL（HRQOL）相关的因素。因此，我们探讨了儿童癌症幸存者体力活动（PA）与 HRQOL 之间的关系。
共有 215 名儿童淋巴瘤、白血病和中枢神经系统癌症幸存者完成了邮寄调查，该调查询问了以代谢当量衡量的休闲时间 PA（LTPA）、HRQOL 以及诊断和人口统计学因素。使用相关性和调整后的回归模型来探讨 LTPA 与 HRQOL 之间的关系。
在总样本中，观察到 LTPA 与总体 HRQOL 之间存在适度但具有统计学意义的线性关联（β=0.17，p<0.01），以及每个相应子量表之间的关联（β=0.11-0.23，p<0.05 至<0.001）。在儿童癌症青少年幸存者中，LTPA 与总体 HRQOL（β=0.27）、癌症担忧（β=0.36）、认知功能（β=0.32）、身体外观（β=0.29）和社会功能（β=0.27）显著相关（均为 p<0.05）。在儿童癌症成年幸存者中，LTPA 仅与身体功能显著相关（β=0.28，p<0.001）。
LTPA 与 HRQOL 之间存在显著关联；然而，这种关联在儿童癌症青少年幸存者中更强，并在更多领域观察到。需要进一步研究来确定该人群中 PA 的前因和后果。
