Davies M, Sabbadini E
J Natl Cancer Inst. 1977 Jul;59(1):263-5. doi: 10.1093/jnci/59.1.263.
The effect of BCG on the development of cell-mediated cytotoxicity (CMC) in the spleens of allogeneic tumor-bearing (C57BL/6 X A)F1 mice was studied. BCG-treated tumor-bearing animals elicited a stronger CMC response than did the untreated tumor-bearing animals. Furthermore, the degree of activation was dependent on different doses of BCG, so that if the BCG was administered at doses above or below the optimum dose, a less marked stimulation of the CMC resulted. The combination of BCG given before the tumor implant plus an intratumor inoculation resulted in a significantly higher CMC than did either treatment alone.
研究了卡介苗对同种异体荷瘤（C57BL/6×A）F1小鼠脾脏中细胞介导的细胞毒性（CMC）发展的影响。经卡介苗处理的荷瘤动物比未处理的荷瘤动物引发更强的CMC反应。此外，激活程度取决于不同剂量的卡介苗，因此，如果卡介苗的给药剂量高于或低于最佳剂量，对CMC的刺激作用就不那么明显。在肿瘤植入前给予卡介苗并结合瘤内接种，所产生的CMC明显高于单独使用任何一种处理方法。
