Molecular cloning and expression of alpha parvalbumin in the guinea pig cochlea.
作者信息
Soto-Prior A, Cluzel M, Renard N, Ripoll C, Lavigne-Rebillard M, Eybalin M, Hamel C P
机构信息
Neurobiologie de l'Audition-Plasticité Synaptique, INSERM U 254, Université de Montpellier.
出版信息
Brain Res Mol Brain Res. 1995 Dec 28;34(2):337-42. doi: 10.1016/0169-328x(95)00205-7.
PMID:8750839
Abstract
We have cloned and sequenced an alpha parvalbumin cDNA from the guinea pig cochlea. The deduced amino acid sequence shows greater identity with the rabbit sequence (86.3%) than with other mammalian sequences (< 82%). Using in situ hybridization and immunohistochemistry, alpha parvalbumin mRNA and protein were found in primary auditory neurons and inner hair cells, in agreement with RT-PCR data showing alpha parvalbumin mRNA expression in the spiral ganglion and the organ or Corti.
摘要
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