Cirimele V, Kintz P, Mangin P
Arch Toxicol. 1995;70(1):68-9. doi: 10.1007/BF03035462.
After external decontamination, the extraction of amphetamine (AP), 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) from hair and fingernails was accomplished via hot alkaline hydrolysis (1 ml 1 N NaOH, 10 min at 95 degrees C) in the presence of deuterated internal standards, followed by a three-step extraction procedure. The target drugs were derivatized by propionylation and analyzed by GC/MS operated in the electronic impact mode. Results indicated that AP, MDA and MDMA were present in both hair and fingernails. Their concentrations, slightly higher in fingernails than in head hair, were 10.2 and 12.0 ng/mg for AP, 8.0 and 9.7 ng/mg for MDA and 53.4 and 60.2 ng/mg for MDMA in head hair and in fingernails, respectively.
在进行外部去污后，在氘代内标存在的情况下，通过热碱性水解（1毫升1N氢氧化钠，95摄氏度下10分钟）从头发和指甲中提取苯丙胺（AP）、3,4-亚甲基二氧基苯丙胺（MDA）和3,4-亚甲基二氧基甲基苯丙胺（MDMA），随后进行三步提取程序。目标药物通过丙酰化衍生，并采用电子轰击模式运行的气相色谱/质谱联用仪进行分析。结果表明，头发和指甲中均存在AP、MDA和MDMA。它们在指甲中的浓度略高于头发，头发中AP的浓度分别为10.2和12.0纳克/毫克，MDA为8.0和9.7纳克/毫克，MDMA为53.4和60.2纳克/毫克，指甲中的浓度分别为上述对应值。
