Nordal R R, Kristensen G B, Kaern J, Stenwig A E, Pettersen E O, Tropé C G
Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo, Norway.
Gynecol Oncol. 1996 Aug;62(2):254-9. doi: 10.1006/gyno.1996.0224.
To evaluate the prognostic significance of DNA ploidy in endometrial stromal sarcoma, the traditional clinical and histopathological prognostic variables and DNA ploidy in 48 patients with histologically verified endometrial stromal sarcoma were analyzed. Evaluable flow cytometric DNA histograms from paraffin-embedded tissue from the tumor were obtained in 47 patients. In univariate analysis, malignancy grade (P < 0.001), cellular atypia (P < 0.001), tumor diameter (P = 0.001), and mitotic count (P = 0.002) were highly significant. Also menopausal status (P = 0.011), FIGO stage (P = 0.035), and free resection margins at primary surgery (P = 0.026) obtained significance, while vessel invasion and age did not. DNA ploidy was not significant. In Cox multivariate analysis, free resection margins at primary surgery were found to be the most important prognostic factor (P < 0.001), followed by malignancy grade (P = 0.002), tumor diameter (P = 0.019), and menopausal status (P = 0.019). DNA ploidy did not obtain significance. Free resection margins at primary surgery, malignancy grade, tumor diameter, and menopausal status are important prognostic factors in endometrial stromal sarcoma.
为评估DNA倍体在子宫内膜间质肉瘤中的预后意义，对48例经组织学证实的子宫内膜间质肉瘤患者的传统临床和组织病理学预后变量及DNA倍体进行了分析。47例患者获得了来自肿瘤石蜡包埋组织的可评估流式细胞术DNA直方图。单因素分析中，恶性程度（P < 0.001）、细胞异型性（P < 0.001）、肿瘤直径（P = 0.001）和有丝分裂计数（P = 0.002）具有高度显著性。绝经状态（P = 0.011）、国际妇产科联盟（FIGO）分期（P = 0.035）以及初次手术时的切缘阴性（P = 0.026）也具有显著性，而血管侵犯和年龄则无显著性。DNA倍体无显著性。在Cox多因素分析中，初次手术时的切缘阴性被发现是最重要的预后因素（P < 0.001），其次是恶性程度（P = 0.002）、肿瘤直径（P = 0.019）和绝经状态（P = 0.019）。DNA倍体无显著性。初次手术时的切缘阴性、恶性程度、肿瘤直径和绝经状态是子宫内膜间质肉瘤的重要预后因素。
