白色念珠菌应激甘露糖蛋白在浅表和全身性念珠菌病中的表达。白色念珠菌中的应激甘露糖蛋白。
Candida albicans stress mannoproteins expression in superficial and systemic candidiasis. Stress mannoproteins in Candida albicans.
作者信息
Pontón J, Hernando F L, Moragues M D, Barea P L, Gerloni M, Conti S, Fisicaro P, Cantelli C, Polonelli L
机构信息
Departamento de Inmunologia, Microbiologia y Parasitología, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Bilbao, Spain.
出版信息
Mycopathologia. 1996;133(2):89-94. doi: 10.1007/BF00439119.
The presence of heat shock mannoproteins (HSMPs) reactive with sIgA was demonstrated in several C. albicans strains. The subculture of the C. albicans isolated from mucosal surfaces on Sabouraud's dextrose agar at 25 degrees C switched off the HSMP expression. A re-expression of the HSMPs was obtained in the same medium by shifting the temperature of incubation to 37 degrees C. However, expression of HSMPs in two strains isolated from deep infections was maintained during several subcultures on Sabouraud's dextrose agar at 25 degrees C. A glycoprotein of 200 kDa seemed to be the main HSMP reacting with vaginal sIgA. The data presented in this study suggest that factors other than temperature can influence the expression of C. albicans HSMPs and therefore these antigens should be referred as stress mannoproteins.
在几种白色念珠菌菌株中证实了存在与分泌型免疫球蛋白A（sIgA）反应的热休克甘露糖蛋白（HSMPs）。从黏膜表面分离的白色念珠菌在25摄氏度的沙氏葡萄糖琼脂上进行传代培养时，HSMP表达关闭。通过将培养温度转移至37摄氏度，在相同培养基中获得了HSMPs的重新表达。然而，从深部感染分离的两种菌株中的HSMPs在25摄氏度的沙氏葡萄糖琼脂上进行多次传代培养期间仍保持表达。一种200 kDa的糖蛋白似乎是与阴道sIgA反应的主要HSMP。本研究中呈现的数据表明，除温度外的其他因素可影响白色念珠菌HSMPs的表达，因此这些抗原应被称为应激甘露糖蛋白。
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