Robert R, Mahaza C, Miegeville M, Ponton J, Marot-Leblond A, Senet J M
Laboratoire d'Immunologie-Mycologie-Bactériologie, UFR des Sciences Médicales et Pharmaceutiques, Angers, France.
Infect Immun. 1996 Sep;64(9):3752-7. doi: 10.1128/iai.64.9.3752-3757.1996.
The binding of resting platelets to Candida albicans germ tubes was studied by means of an affinity column in which germ tubes were physically immobilized. Adhesion of platelets to the column was dependent on both the germ tube concentration and the number of platelets applied. It was found that the interaction of C. albicans germ tubes with platelets is specific and should be mediated by a fungal protein receptor. The results obtained by scanning electron microscopy confirmed that resting platelets can fix directly onto germ tubes. In addition, this study showed that attachment of platelets onto C. albicans is associated with morphological changes. Platelets lost their discoid shape, became globular, generated spikes or pseudopods, and then flattened on the yeast cells.
通过一个将芽管物理固定的亲和柱研究了静息血小板与白色念珠菌芽管的结合。血小板与柱的黏附取决于芽管浓度和所加血小板的数量。发现白色念珠菌芽管与血小板的相互作用是特异性的，且应由一种真菌蛋白受体介导。扫描电子显微镜获得的结果证实静息血小板可直接固定在芽管上。此外，该研究表明血小板在白色念珠菌上的附着与形态变化有关。血小板失去其盘状形态，变成球状，产生刺或伪足，然后在酵母细胞上变平。
