转化生长因子β对小鼠抵抗单核细胞增生李斯特菌感染具有保护作用。
Transforming growth factor beta is protective in host resistance against Listeria monocytogenes infection in mice.
作者信息
Nakane A, Asano M, Sasaki S, Nishikawa S, Miura T, Kohanawa M, Minagawa T
机构信息
Department of Bacteriology, Hirosaki University School of Medicine, Japan.
出版信息
Infect Immun. 1996 Sep;64(9):3901-4. doi: 10.1128/iai.64.9.3901-3904.1996.
Abstract
The role of transforming growth factor beta (TGF-beta) in host resistance against Listeria monocytogenes infection was studied with mice. The constitutive expression of TGF-beta 1 mRNA was observed in the spleens and livers of mice before and after infection. Injecting the mice with anti-TGF-beta 1 peptide serum resulted in diminished antilisterial resistance, whereas the administration of human platelet-derived TGF-beta 1 enhanced the resistance. Moreover, mice were protected against lethal infection when treated with TGF-beta 1. These results suggest the TGF-beta 1 might be involved in antilisterial resistance. On the other hand, injecting the mice with TGF-beta 1 resulted in a decrease in the titers of endogenous gamma interferon, tumor necrosis factor alpha, and interleukin-6, which are crucial in antilisterial resistance, in sera and in extracts of spleen and liver. Thus, a complicated mechanism might be involved in the role of TGF-beta 1 in host resistance against L. monocytogenes infection.
摘要
利用小鼠研究了转化生长因子β（TGF-β）在宿主抗单核细胞增生李斯特菌感染中的作用。在感染前后的小鼠脾脏和肝脏中均观察到TGF-β1 mRNA的组成性表达。给小鼠注射抗TGF-β1肽血清会导致抗李斯特菌抵抗力减弱，而给予人血小板衍生的TGF-β1则增强了抵抗力。此外，用TGF-β1治疗的小鼠对致死性感染具有抵抗力。这些结果表明TGF-β1可能参与了抗李斯特菌抵抗力。另一方面，给小鼠注射TGF-β1会导致血清以及脾脏和肝脏提取物中内源性γ干扰素、肿瘤坏死因子α和白细胞介素-6的滴度降低，而这些在抗李斯特菌抵抗力中至关重要。因此，TGF-β1在宿主抗单核细胞增生李斯特菌感染中的作用可能涉及复杂的机制。
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