抗伴放线放线杆菌Y4（b血清型）脂多糖对早发性广泛性牙周炎严重程度的影响
Influence of anti-Actinobacillus actinomycetemcomitans Y4 (serotype b) lipopolysaccharide on severity of generalized early-onset periodontitis.
作者信息
Califano J V, Gunsolley J C, Nakashima K, Schenkein H A, Wilson M E, Tew J G
机构信息
Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0566, USA.
出版信息
Infect Immun. 1996 Sep;64(9):3908-10. doi: 10.1128/iai.64.9.3908-3910.1996.
Abstract
The objective of this study was to determine if a relationship exists between antibody reactive with the Actinobacillus actinomycetemcomitans serotype b lipopolysaccharide (LPS) and severity of periodontal disease in generalized early-onset periodontitis (G-EOP). The concentration of antibody reactive with A. actinomycetemcomitans serotype b LPS was determined for 102 G-EOP subjects. Analysis of the relationship between antibody reactive with A. actinomycetemcomitans serotype b LPS and measures of periodontal attachment loss indicated that the patients with the highest concentrations of antibody reactive with A. actinomycetemcomitans serotype b LPS had significantly less attachment loss. These high-responder subjects also had anti-A. actinomycetemcomitans serotype b LPS with significantly higher relative avidity. The results suggest that antibody reactive with A. actinomycetemcomitans serotype b LPS is protective in G-EOP patients.
摘要
本研究的目的是确定与伴放线放线杆菌b型血清型脂多糖（LPS）发生反应的抗体与广泛型早发性牙周炎（G-EOP）患者牙周疾病严重程度之间是否存在关联。测定了102例G-EOP患者血清中与伴放线放线杆菌b型血清型LPS发生反应的抗体浓度。对与伴放线放线杆菌b型血清型LPS发生反应的抗体和牙周附着丧失指标之间的关系进行分析，结果显示，血清中与伴放线放线杆菌b型血清型LPS发生反应的抗体浓度最高的患者，其附着丧失显著较少。这些高反应性受试者体内抗伴放线放线杆菌b型血清型LPS的相对亲和力也显著更高。结果表明，与伴放线放线杆菌b型血清型LPS发生反应的抗体对G-EOP患者具有保护作用。
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