恙虫病立克次体感染诱导小鼠淋巴细胞凋亡
Apoptosis of lymphocytes in mice induced by infection with Rickettsia tsutsugamushi.
作者信息
Kasuya S, Nagano I, Ikeda T, Goto C, Shimokawa K, Takahashi Y
机构信息
Department of Parasitology, Gifu University School of Medicine, Japan.
出版信息
Infect Immun. 1996 Sep;64(9):3937-41. doi: 10.1128/iai.64.9.3937-3941.1996.
Abstract
Histological examinations of mice infected with either a lethal (Karp) or a self-limitating (Gilliam) strain of Rickettsia tsutsugamushi were performed. Tingible body macrophages in the spleen and necrotizing lymphadenitis in regional lymph nodes were prominent only in the former. Apoptotic legions in the lymphocytes of these organs were clearly demonstrated by histochemical and electron microscopical examinations.
摘要
对感染致死型（卡尔普株）或自限型（吉列姆株）恙虫病立克次体的小鼠进行了组织学检查。脾脏中的吞噬细胞和局部淋巴结中的坏死性淋巴结炎仅在前者中较为明显。通过组织化学和电子显微镜检查清楚地证实了这些器官淋巴细胞中的凋亡小体。
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