Cramer J A
Department of Psychiatry, Yale University School of Medicine, New Haven, USA.
Obstet Gynecol. 1996 Sep;88(3 Suppl):4S-12S. doi: 10.1016/0029-7844(96)00248-7.
To define some of the issues unique to compliance with oral contraceptives, and some comparisons with other preventive and therapeutic treatments.
Reports of compliance with medical treatment were used, with a focus on studies using microelectronic monitoring to assess compliance. Studies included the general population and a variety of demographically different groups.
Twenty-nine studies of medication compliance (including surveys and clinical trials with specific interventions), across a broad range of medical disorders, were selected for comparison with reports of oral contraceptive compliance.
TABULATION, INTEGRATION, AND RESULTS: Rates of compliance with contraceptive methods are low, but differ little from rates of compliance with other medical treatments. Several questions might be used to ascertain the likelihood that an individual is willing to use an oral contraceptive as prescribed (eg, willingness to take a daily pill, to return for follow-up, and to report adverse effects).
Studies of a variety of medical disorders have shown that no consequence is so severe that all patients can be assumed to comply with the prescribed treatment plan. Inadequate compliance often diminishes treatment efficacy, which suggests the need for alternative methods that do not require daily compliance.
明确口服避孕药依从性所特有的一些问题，以及与其他预防和治疗性疗法的一些比较。
使用了关于药物治疗依从性的报告，重点是采用微电子监测来评估依从性的研究。研究对象包括普通人群以及各种人口统计学特征不同的群体。
选取了29项关于药物依从性的研究（包括调查和有特定干预措施的临床试验），这些研究涉及广泛的医学病症，用于与口服避孕药依从性报告进行比较。
制表、整合与结果：避孕方法的依从率较低，但与其他药物治疗的依从率差异不大。可以使用几个问题来确定个体按规定使用口服避孕药的可能性（例如，愿意每天服药、愿意复诊以及报告不良反应）。
对各种医学病症的研究表明，没有哪种后果严重到可以假定所有患者都会遵守规定的治疗方案。依从性不足往往会降低治疗效果，这表明需要有无需每日依从的替代方法。
