Gentsch J R, Woods P A, Ramachandran M, Das B K, Leite J P, Alfieri A, Kumar R, Bhan M K, Glass R I
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Infect Dis. 1996 Sep;174 Suppl 1:S30-6. doi: 10.1093/infdis/174.supplement_1.s30.
Candidate rotavirus vaccines have been prepared with reassortant strains specifically to protect against the 4 major rotavirus G serotypes (G1 -4). Many studies using P (VP4) genotyping methods have indicated that, worldwide, rotavirus strains of the 4 common G serotypes are each associated with 1 P genotype: GI, G3, and G4 are associated with P[8], and G2 is associated with P[4]. In contrast, G and P genotyping of rotavirus in specimens from India revealed that a high percentage of the childhood diarrhea strains belong to genotype P[6], and the most common strain had an unusual G serotype, G9. Similarly, in all regions surveyed in Brazil, apparent reassortants of genotype P[8], G5 were found in children with gastroenteritis. These studies indicate that while rotavirus strains have limited diversity in many settings, reassortment between common and uncommon serotypes or animal strains can arise in some settings and, thus, lead to unusual diversity.
候选轮状病毒疫苗是用重配株制备的，专门用于预防4种主要的轮状病毒G血清型（G1-4）。许多使用P（VP4）基因分型方法的研究表明，在全球范围内，4种常见G血清型的轮状病毒株各自与1种P基因型相关：G1、G3和G4与P[8]相关，G2与P[4]相关。相比之下，对印度标本中轮状病毒的G和P基因分型显示，儿童腹泻菌株中有很大比例属于P[6]基因型，最常见的菌株具有不寻常的G血清型G9。同样，在巴西所有调查地区，患有肠胃炎的儿童中发现了P[8]、G5基因型的明显重配株。这些研究表明，虽然轮状病毒株在许多情况下多样性有限，但在某些情况下，常见和不常见血清型或动物株之间可能会发生重配，从而导致不寻常的多样性。
