Watanabe Y
Department of Public Health, Hokkaido University School of Medicine, Sapporo, Japan.
Hokkaido Igaku Zasshi. 1996 May;71(3):391-402.
In the treatment of senile dementia, rehabilitation rather than drugs, could result in more positive long-term effects. A Day Care program designed for individuals with Senile Dementia of the Alzheimer type (SDAT) and Vascular Dementia (VD:MID and BD), activates the brain through memory training, creative arts therapy, physical activity, and social interaction. The objective of this study is to determine if Day Care can modify the patients intellectual decline or even alter the natural course of the dementing illness. 135 SDAT and 213 VD patients were studied over three years. ADL (Activities of Daily Living) measurements were evaluated by the Barthel Index and cognitive measurements by the NM-scale. The Wilcoxon test and the Sign test were carried out using the BI and NM-scale scores. These results indicated a decline or arrest in the progression of SDAT and VD as determined by the multiple logistical models. The 8 variables (risk factors, medication, age at onset, self-rehabilitation, family support, sex, grade of dementia and Day Care) influence on the survival curves was calculated using the Kaplan-Meire Life table method. The Cox proportional hazard analysis was then used to examine the relationship between the 8 variables and dementia. The significantly positive results from these four analyses of the ADL and cognitive measurements indicate that Day Care programs clearly retards the progression of intellectual decline in dementia patients and improves the quality of life (QOL) in all cases. In VD patients the mortality rate was notably decreased through Day Care. These results make one consider the benefits of introducing such programs into society as a strong treatment against the onset of dementia developing into severe, dehabilitating dementia. However a healthy diet, a physically and mentally active life, as well as early diagnosis, are the best preventions against dementia.
在老年痴呆症的治疗中,康复而非药物治疗可能会产生更积极的长期效果。一个为阿尔茨海默型老年痴呆症(SDAT)和血管性痴呆(VD:MID和BD)患者设计的日托项目,通过记忆训练、创意艺术疗法、体育活动和社交互动来激活大脑。本研究的目的是确定日托是否能改善患者的智力衰退,甚至改变痴呆症的自然病程。对135名SDAT患者和213名VD患者进行了为期三年的研究。通过巴氏指数评估日常生活活动(ADL)测量结果,通过NM量表评估认知测量结果。使用BI和NM量表分数进行Wilcoxon检验和符号检验。这些结果表明,根据多重逻辑模型确定,SDAT和VD的进展有所下降或停止。使用Kaplan-Meire生命表法计算8个变量(风险因素、药物治疗、发病年龄、自我康复、家庭支持、性别、痴呆等级和日托)对生存曲线的影响。然后使用Cox比例风险分析来检查这8个变量与痴呆症之间的关系。对ADL和认知测量的这四项分析得出的显著积极结果表明,日托项目明显延缓了痴呆症患者智力衰退的进展,并在所有情况下提高了生活质量(QOL)。在VD患者中,通过日托显著降低了死亡率。这些结果促使人们考虑将此类项目引入社会的好处,作为对抗痴呆症发展为严重、致残性痴呆症的有效治疗方法。然而,健康的饮食、积极的身心生活以及早期诊断是预防痴呆症的最佳方法。