Sáenz Calvo A, Ausejo Segura M, Cruz Martos E, González Alvaro A, Pérez Cayuela P, Rosado López A
Centro de Salud Gómez Acebo, Insalud, Area/Sector XI de Madrid.
Aten Primaria. 1996 May 31;17(9):559-63.
To describe suspects of drug interactions in primary health care.
Descriptive and transversal study during 1 month.
Urban health center, primary care, Madrid (Spain).
Patients were treated simultaneously with more than 1 drug (145), 2 general practitioners (GP) and 1 pharmacist.
GP registered in a sheet-form data from diagnostic and pharmacological treatments. The pharmacist checked the sheet-forms to detect drug interactions, and later assessed to the GP about it. The proposals were classified in 3 ways: no change in treatment; to modify or stop the current treatment, and to monitor plasmatic level or clinical parameters.
333 drug interactions were detected in 145 patients. The 67.5% of interactions produced by 7 groups of drugs: theophylines, diuretics, antacids, benzodiacepines, betablockers, NSAID's and ACE's. GP accepted 74% of pharmacist's proposals (recommendations).
Seven types of drugs were involved in the main interactions in primary care. The drug interactions increased as more drugs takes a patient in an accelerated trend. Older than 55 were the most affected. GP accepted 3/4 of the recommended pharmacist proposals.
描述初级卫生保健中药物相互作用的疑似情况。
为期1个月的描述性横断面研究。
西班牙马德里的城市卫生中心，初级保健机构。
同时接受超过1种药物治疗的患者（145名）、2名全科医生（GP）和1名药剂师。
全科医生以表格形式记录诊断和药物治疗的数据。药剂师检查表格以检测药物相互作用，随后就此向全科医生进行评估。建议分为3种：治疗方案不变；修改或停止当前治疗，以及监测血浆水平或临床参数。
在145名患者中检测到333起药物相互作用。67.5%的相互作用由7类药物引起：茶碱类、利尿剂、抗酸剂、苯二氮䓬类、β受体阻滞剂、非甾体抗炎药和血管紧张素转换酶抑制剂。全科医生接受了药剂师74%的建议（推荐）。
初级保健中的主要相互作用涉及7类药物。患者服用的药物越多，药物相互作用增加的趋势越快。55岁以上人群受影响最大。全科医生接受了药剂师3/4的推荐建议。
