Sáenz Calvo A, Ausejo Segura M, Bórdas Rodríguez I, Acuña Aller R, Gónzalez Alvaro A, Bellas Beceiro B
Centro de Salud Gómes, Acebo, INSALUD, Area/Sector xi di Madrid.
Aten Primaria. 1995 May 15;15(8):516-8.
To describe adverse drug effects (ADE) and their frequency in primary care patients.
Descriptive and longitudinal study during 1 year (1990).
Urban Health Center. Primary Care. Madrid (Spain).
15,483 persons, nine general practitioner and one pharmacist.
Doctors were invited to register any adverse drug effects they had notice in their patients. Doctors registered information and gave notice to the pharmacist about medicines, dosage and period of administration, clinical manifestations, and improving or not if drug was withdrawal.
326 adverse drugs effects were notified, 30.9 ADE per thousand attended patients. 117 principles actives were involved, and 415 clinical manifestations were registered. The more affected patients were women (2/1). The age groups with higher ADE relative frequencies were children under one year and older people.
The absolute frequency of medicines involved in ADE are different to relative frequencies when ADE per thousand prescription units are used. Some of the ADE notified were not referred before in the bibliography, so primary care is a good place to research on pharmacosurveillance.
描述基层医疗患者的药物不良反应（ADE）及其发生频率。
为期1年（1990年）的描述性纵向研究。
城市健康中心。基层医疗。马德里（西班牙）。
15483人、9名全科医生和1名药剂师。
邀请医生记录他们在患者中注意到的任何药物不良反应。医生记录信息并向药剂师通报药物、剂量和给药期、临床表现，以及停药后症状是否改善。
共通报了326例药物不良反应，每千名就诊患者中有30.9例ADE。涉及117种活性成分，记录到415种临床表现。受影响较多的患者为女性（男女比例为2/1）。ADE相对频率较高的年龄组是1岁以下儿童和老年人。
当采用每千个处方单位的ADE计算时，涉及ADE的药物绝对频率与相对频率不同。一些通报的ADE在文献中之前未被提及，因此基层医疗是药物监测研究的良好场所。
