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[Synthesis and antibacterial properties of quinoxaline 1,4-dioxide derivatives].

作者信息

Takabatake T, Takabatake Y, Miyazawa T, Hasegawa M

机构信息

College of Pharmacy, Nihon University, Chiba, Japan.

出版信息

Yakugaku Zasshi. 1996 Jun;116(6):491-6. doi: 10.1248/yakushi1947.116.6_491.

DOI:10.1248/yakushi1947.116.6_491
PMID:8753069
Abstract

Novel quinoxaline 1,4-dioxide derivatives were synthesized from benzofuroxans and the enolic form of 1,3-diketones or 3-oxoalkanoic esters or 3-oxoalkanamides or butanedioic esters catalyzed by silica gel or molecular sieves and their antibacterial activities were evaluated. As the results of antibacterial screening tests in vitro, quinoxaline 1,4-dioxides revealed strong activities against Bacteroides fragilis.

摘要

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