Miyazawa T, Takabatake T, Hasegawa M
College of Pharmacy, Nihon University, Chiba, Japan.
Yakugaku Zasshi. 1997 Feb;117(2):126-32. doi: 10.1248/yakushi1947.117.2_126.
Novel pyrido[2,3-b]pyrazine 1,4-dioxide and pyrido [2,3-b]pyrazine 1-oxide derivatives were synthesized from furazano [4,5-b]pyridine 3-oxide and the enolic form of 1,3-diketones or beta-ketoesters catalyzed by silica gel or molecular sieves. Their antibacterial activities were evaluated. As the results of anti-bacterial screening tests in vitro, pyrido[2,3-b]pyrazine 1,4-dioxide derivatives revealed strong activities, but pyrido[2,3-b]pyrazine 1-oxide derivatives revealed no activities.
新型吡啶并[2,3 - b]吡嗪1,4 - 二氧化物和吡啶并[2,3 - b]吡嗪1 - 氧化物衍生物由呋咱并[4,5 - b]吡啶3 - 氧化物与1,3 - 二酮或β - 酮酯的烯醇式在硅胶或分子筛催化下合成。对它们的抗菌活性进行了评估。作为体外抗菌筛选试验的结果，吡啶并[2,3 - b]吡嗪1,4 - 二氧化物衍生物显示出较强活性，但吡啶并[2,3 - b]吡嗪1 - 氧化物衍生物未显示出活性。
